Despite such a wide-ranging primary prevention activities, the number of patients with colon cancer is increasing annually. In particular, in the United States in 2013, 102,480 patients with primary CC were detected. In Samarkand, 46 patients with primary colon cancer were identified in 2012, 24 of them men and 22 women. The structure of the incidence of colon cancer is in the tenth place in Samarkand, and in the Republic of Uzbekistan it is the eighth place.