From this perspective, the study of immunological and genetic mechanisms of the pathogenesis of this disease for the construction of rational treatment and prevention emphasizes the relevance of this thesis research.It is known that the key immune mechanisms in the pathogenesis of the vast majority of BA cases is real and indisputable fact (Gaymolenko I.N., 2004; Bogatyreva E.V., 2007; Kryvtsov A.V., et al., 2007; Kovalev V.L., et al