Pediatric brain tumors are the most common solid tumors and the most common cause of death at pediatric cancer [9]. The 2016-edition of the World Health Organization (WHO) classification of tumours for central nervous system presentes major restructuring of diffuse gliomas, medulloblastomas and other embryonal tumors, and, also incorporated new entities that were defined by both histology and molecular features, including glioblastoma, IDH-wildtype and glioblastoma, IDH-mutant; diffuse midline glioma, H3 K27M-mutant; RELA fusion-positive ependymoma; medulloblastoma, WNT-activated and medulloblastoma, SHH-activated; and embryonal tumour with multilayered rosettes, C19MC-al- tered